Since making his motion picture debut in One Flew Over the Cuckoo's Nest, a role which garnered him an Academy AwardŽ nomination, a Golden Globe Award, and a BAFTA Award, Brad Dourif has appeared in over fifty films. His film credits include Ragtime, Mississippi Burning, The Eyes of Laura Mars, Wise Blood, Blue Velvet, Dune, The Exorcist III, Hidden Agenda, Jungle Fever, Murder in the First, The Color of Night, Nightwatch, and Senseless, to name just a few. He received the Fangoria Chainsaw Award for Best Supporting Actor for his role in Body Parts, and a Genie Award Nomination for Best Actor for his role in Common Bonds. He has also appeared in the Jean Pierre Jeunet's Alien Resurrection, the independent films Soulkeeper, The Ghost and Brown's Requiem, and played the "Voice of Chucky" in all four Child's Play films.

For television, Dourif has guest-starred on such series as Millennium, The X-Files, and Tales From The Crypt, and was a series regular on ABC's The Secret Lives of Men. His movie-of-the-week and mini-series credits include Escape To Witch Mountain, Crusaders, Stamper's Rampage, Oliver Stone's Wild Palms, Steven Spielberg's Class of '61, and Rage of Angels.

Dourif's stage credits include the title role in the Off-Broadway production of When You Comin' Back Red Ryder. He was a founding member of New York's Circle Repertory Theater.